Expression of Adhesion Molecules(ICAM-1, VCAM-1, ELAM-1) in Middle Ear Cholesteatoma Tissues
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چکیده
منابع مشابه
maprotiline inhibits lps-induced expression of adhesion molecules (icam-1 and vcam-1) in human endothelial cells
regardless of the known anti-inflammatory potential of heterocyclic antidepressants, the mechanisms concerning their modulating effects are not completely known. in our earlier work, maprotiline, a heterocyclic antidepressants, considerably inhibited infiltration of polymorphonuclear cell leucocytes into the inflamed paw. to understand the mechanism involved, we evaluated the effect of vascular...
متن کاملthe study of soluble adhesion mol¬ecules (sicam-1, svcam-1, selam-1) in se¬rum and membrane form of adhesion molecules (vcam-1, icam-1) on the mono¬cytes in diabetic subjects type 1
the adhesion molecules are involved in adhesion of leukocytes to endothelial cells and other immune cells. not only adhesion molecules have membrane form, but they also have soluble form. in this paper, we attempted to investigate the concen¬tration of soluble adhesion molecules in the type 1 diabetic patients (n = 40) and healthy subjects (n = 10). the results indicated that there was an incre...
متن کاملFull length vascular cell adhesion molecule 1 (VCAM-1).
We have developed several monoclonal antibodies that bind specifically to IL-1 activated but not to quiescent human unbilical vein endothelial cells (HUVEC). Two antibodies, 1E7 and 2G7, were shown to react at distinct epitopes with a novel IL-1 inducible sialoglycoprotein which is implicated in the adhesion of T cells with activated endothelium (1). We used polymerase chain reaction (PCR, 2, 3...
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Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively. Integrin costimulatory signals modulate inflammatory gene expression, but the important control points between these pathways remain unresolved. We report ...
متن کاملFour molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions
T cell adhesion to endothelium is critical to lymphocyte recirculation and influx into sites of inflammation. We have systematically analyzed the role of four receptor/ligand interactions that mediate adhesion of peripheral human CD4+ T cells to cultured human umbilical vein endothelial cells (HUVEC): T cell LFA-1 binding to ICAM-1 and an alternative ligand ("ICAM-X"), T cell VLA-4 binding to V...
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ژورنال
عنوان ژورنال: Journal of Clinical Otolaryngology Head and Neck Surgery
سال: 2002
ISSN: 1225-0244,2713-833X
DOI: 10.35420/jcohns.2002.13.1.65